The Phosphorus-Mediated Oligomerization of Glycinesters

Abstract

The catalytic polymerization of α-aminoacids or stable α-aminoesters in the presence of a phosphorus template is proposed as an alternative to that of sensitive N-carboxyanhydrides for the synthesis of polyaminoacids. The synthesis of methane thiophosphonyl derivatives of polyglycine (an average of ten residues) was actually carried out in polar solvents (dimethylformamide, acetonitrile) in the presence of diazabicycloundecene and trimethylsilyldiethylamine.

keywords:

• Cyclization
• peptides
• phosphorus
• polycondensation
• silicon