Novel Quinazolinone Derivatives as Possible Antitumor Agents

Abstract

The synthesis of a novel series of quinazolinone derivatives 6–15 having the biologically active thioxo group utilizing 2-isothiocyanato-benzoic acid methyl ester 2 is reported. Their structures have been confirmed on the basis of elemental analyses and (IR, ¹H NMR, and mass) spectral data. Preliminary testing for the in vitro antitumor activity of some synthesized compounds against Ehrlich Ascities Carcinoma cells was carried out.

Keywords:

• Antitumor activity
• quinazoline-4(3H)-one

Notes

*IC₅₀ > 100 (μg/mL) is considered to be inactive.