Convenient Synthesis of Some Thiadiazolotriazinones Carrying 4-Methylthiobenzyl Moieties as Possible Antimicrobial Agents

Abstract

4-amino-6-(4-methylthiobenzyl)-3-mercapto-1,2,4-triazin-5(4H)-one was condensed with various substituted benzoic acids/aryloxyacetic acids in the presence of phosphorus oxychloride to afford a series of 7-(substituted aryl/aryloxymethyl)-3-(4-methylthiobenzyl)-4H-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4-ones in good yields. The structures of the newly synthesized compounds were confirmed on the basis of elemental analysis, IR, ¹H NMR, and mass spectral studies. All the newly synthesized compounds were tested for their antibacterial and antifungal activity against a variety of microorganisms.

Keywords:

• 1,3,4-Thiadiazole
• 1,2,4-triazin-5(4H)-one
• antibacterial
• antifungal

Acknowledgments

The authors are thankful to the head of CDRI, Lucknow, and the head of SAIF, IISc, Bangalore, for providing the mass and ¹H NMR spectral data. The authors are also grateful to Dr. Suchetha Kumari N, Department of Biochemistry, K.S. Hegde Medical Academy, Deralakatte, Mangalore, for providing antimicrobial activity data for the newly synthesized compounds.