Synthesis and In-Vitro Antimicrobial Activity of Some Heterocyclic Compounds via 7H-1,2,4-triazolo[1,5-d]tetrazol-6-ylsulfanyl Acetic Acid Hydrazide

Abstract

{7 H-1,2,4-triazolo[1,5-d]tetrazol-6-ylsulfanyl} acetic acid hydrazide was utilized by different reagent, namely isothiocyanates, formic acid, triethyl orthoformate, and carbon disulfide, to yield the corresponding compounds, which were cyclized to construct 1,2,4-triazoles, 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles. The structure of the products was deduced through physicochemical as well as spectral data (IR, ¹ H NMR, and MS). Representative members of the prepared compounds were tested for antimicrobial activity.

Keywords:

• {7H-1,2,4-triazolo[1,5-d]tetrazol-6-ylsulfanyl} acetic acid hydrazide
• antimicrobial activity
• structure elucidation
• synthesis
• various heterocyclic systems

Acknowledgments

This article is Part III of a series. For Part II, see ref. 1.