Synthesis of Some Thiadiazolotriazinone Derivatives as Possible Antimicrobial Agents

Abstract

A series of 7-substituted-3-t-butyl 4(H)-1,3,4-thiadiazolo(2,3-c)-1,2,4-triazine-4-one (3) have been synthesized by condensing 4-amino-6-t-butyl-3-mercapto-1,2,4-triazin-5(4H)-one (1) with substituted Arylfuroic acids (2) using POCl₃ as a cyclizing agent. The newly synthesized compounds are characterized by elemental analysis, IR, ¹H NMR, and mass spectral studies. The compounds were screened for their antibacterial and antifungal activities. Some of the compounds showed promising antibacterial and antifungal activity.

Keywords:

• Antimicrobial
• Aryl furoic acids
• phosphorus oxychloride
• thiadiazolotriazinones

Acknowledgments

The authors are thankful to IISc, Bangalore, CDRI, Lucknow, and Department of Chemistry, Mangalore University for providing NMR/Mass/IR spectra of the compounds reported. The authors are also thankful to the Government of India, Department of Science and Technology, for providing CHNS Instrument Facility under DST-FIST fund in the Department of Chemistry, Mangalore University, Mangalagangotri.