Synthesis of Bis(7-Methyl-2- or 6-Purinyl) Disulfides

Abstract

Substituted 7-methyl-2- or 6-purinethiones were obtained in series of reactions by nucleophilic substitution with oxygen, chloro, and sulfur nucleophiles. Oxidation of the sulfur atom at position 6 or 2 in purinethiones to corresponding disulfides depended on the conditions of the reaction and oxidizing agent.

Keywords:

• 7-Methyl-2 or 6-purinethiones
• bis(7-methyl-2- or 6-purinyl) disulfides
• oxidation reaction