Synthesis of Some New 2-(4-Nitrobenzothiazol-2′-ylamino)-4-(2-chloro-4-trifluoromethylanilino)-6-(substituted Thioureido)-1,3,5-triazines as Antifungal Agents

Abstract

Some new 2-(4-nitrobenzothiazol-2′-ylamino)-4-(2-chloro-4-trifluoro-methylanili- no)-6-(substituted thioureido)-1,3,5-triazine 4 have been prepared by reacting 2,4,6-trichloro-1,3,5-triazine with nucleophilic reagents, 2-amino-4-nitrobenzothiazol 1 , 2-chloro-4-trifluoromethylaniline 2 and different substituted thioureas 3 to give the title compound. These compounds are evaluated for their antimicrobial activity. The structure of all of these compounds has been confirmed by IR, ¹ H NMR, ¹⁹ F NMR, mass spectral data and elemental analysis.

Keywords:

• 2-(4-Nitrobenzothiazol-2′-ylamino)-4,6-dichloro-1,3,5-triazine
• 2-(4-Nitrobenzothiazol-2′-ylamino)-4-(2-chloro-4-trifluoromethyl-anilino) -6-chloro-1,3,5-triazine
• 2- (4-Nitrobenzothiazol-2′-ylamino) -4-(2-chloro-4-trifluoromethylanilino)-6-(substituted thioureido)-1,3,5-triazine
• antimicrobial activity