Synthesis and Biological Activities of Some New Phenothiazines, Their Sulfones, and Ribofuranosides

Abstract

The present communication describes the synthesis of substituted 10H-phenothiazines by reaction of 2-aminobenzenethiol 1 and o-halonitrobenzene 2 via Smiles rearrangement. These synthesized phenothiazines are used as base to prepare ribofuranosides by treatment with sugar viz. β -D-ribofuranosyl-1-acetate-2,3,5-tribenzoate. Sulfones are also synthesized by oxidation of 10H-phenothiazines refluxing with H₂O₂ in glacial acetic acid. All synthesized compounds have been characterized by IR, ¹ H NMR, ¹³ C NMR Mass spectra and elemental analysis and screened for antioxidant and antimicrobial activity.

Keywords:

• Antimicrobial activity
• antioxidant activity
• glacial acetic acid
• 10H-phenothiazines
• ribofuranosides

Acknowledgments

The authors are thankful to Head, Department of Chemistry of University of Rajasthan, for providing necessary facilities. Thanks are due to UGC Bhopal for financial support. Thanks are also due to SAIF, CDRI Lucknow for providing 13C NMR and Mass spectra.