Synthesis, Separation and Characterization of Thiacalix[4]arenes Diastereomers

Abstract

Two different 1 , 3-Distal thiacalix[4]arenas were prepared by the reaction of thiacalix[4]arene with phenacyl and/or p-nitro phenacyl bromide in acetone or acetonitrile in the presence of dry CsOH. The prepared 1, 3-distal disubstituted thiacalixarenes afforded two pairs of diastereomers upon brominating in chloroform. The obtained diastereomers were separated by fractional crystallization in a mixture dichloromethane-acetone.

Keywords:

• Bromination
• diastereomers
• separation
• thiacalixarene

Acknowledgments

This work was supported by the Bibliotheca Alexandrina-Center for special studies and programs under Grant No. (04041083).