Recent Advances in Polyphosphoester and Polyphosphoramidate-Based Biomaterials

Abstract

Polyphosphoesters and polyphosphoramidates are important two classes of phosphorous-containing polymers, which have received more and more attention in the past decade for the application in biomedical field. The unique characteristic of biodegradation, biocompatibility and structure versatility of polyphosphoesters and polyphosphoramidates makes it possible to develop a variety of novel phosphate-based polymers for drug delivery, gene delivery and tissue engineering. In this review, we highlighted the recent advances in polyphosphoester and polyphosphoramidate-based biomaterials including synthesis and characterization, degradation, biocompatibility, and important application in drug delivery, gene delivery and nerve repairing.

Keywords:

• Biodegradable
• drug delivery
• gene delivery
• nerve guide conduit
• polyphosphoester
• polyphosphoramidate

Acknowledgments

This work was financially supported by National Key Basic Research Program of China (2005CB623903) and National Natural Science Foundation of China (20474045, 20674058).