Development of the Synthesis Methods of Polyheterophosphacyclanes with Endocyclic P-C Bond on the Basis of Functionalized Alkylphosphonates (-Phosphinates)

Abstract

We developed a new approach to the synthesis of saturated and unsaturated phosphoruselementocontaining heterocycles was developed; we based it on the addition reactions of various proton nucleophiles (amines, silylamines, alcoholes, mercaptanes, aminoalkylphosphonates, phosphines, CH-acides, etc.) to the halogenmethylphosphonylated isocyanates or isothiocyanates. Intermediate compounds of these reactions (phosphorylated ureas, thioureas, urethanes, thiouretanes, acylamides, etc.) are easily transformed into phosphorus containing cyclic structures.

Keywords:

• Addition reactions
• intramolecular cyclization
• polyheterophosphacyclanes
• posphorylated iso(thio)cyanates
• proton nucleophiles

Acknowledgments

The authors are grateful to the Russian Foundation for Basic Research for support of this work (grant no. 06-03-32085).