Cationic Lipids Based on Phosphonate and Phosphoramidate Chemistry: Synthesis and Application to Gene Therapy

Mathieu Mével CEMCA, UMR CNRS 6521, Faculté des Sciences et Techniques, Université de Bretagne Occidentale, Brest, France

Jean-Jacques Yaouanc CEMCA, UMR CNRS 6521, Faculté des Sciences et Techniques, Université de Bretagne Occidentale, Brest, France

Pascale Laurent CEMCA, UMR CNRS 6521, Faculté des Sciences et Techniques, Université de Bretagne Occidentale, Brest, France

Jean-Claude Clément CEMCA, UMR CNRS 6521, Faculté des Sciences et Techniques, Université de Bretagne Occidentale, Brest, France

Dominique Cartier CEMCA, UMR CNRS 6521, Faculté des Sciences et Techniques, Université de Bretagne Occidentale, Brest, France

Paul-Alain Jaffrès CEMCA, UMR CNRS 6521, Faculté des Sciences et Techniques, Université de Bretagne Occidentale, Brest, France

Tristan Montier Unité INSERM 613 “Génétique Moléculaire et Epidémiologie Génétique”, Institut de Synergie des Sciences et de la Santé, Faculté de médecine et des sciences de la santé, Université de Bretagne Occidentale, Brest, France

Pascal Delépine Unité INSERM 613 “Génétique Moléculaire et Epidémiologie Génétique”, Institut de Synergie des Sciences et de la Santé, Faculté de médecine et des sciences de la santé, Université de Bretagne Occidentale, Brest, France

Tony Le Gall Unité INSERM 613 “Génétique Moléculaire et Epidémiologie Génétique”, Institut de Synergie des Sciences et de la Santé, Faculté de médecine et des sciences de la santé, Université de Bretagne Occidentale, Brest, France

Pierre Lehn Unité INSERM 613 “Génétique Moléculaire et Epidémiologie Génétique”, Institut de Synergie des Sciences et de la Santé, Faculté de médecine et des sciences de la santé, Université de Bretagne Occidentale, Brest, France

Chantal Pichon Centre de Biophysique Moléculaire, Orléans, France

Patrick Midoux Centre de Biophysique Moléculaire, Orléans, France

Claude Férec Centre de Biophysique Moléculaire, Orléans, France

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Abstract

Cationic lipids having a phosphorus group (phosphonate or phosphoramidate) to link the lipidic part to a cationic head form an efficient family of vectors for DNA delivery. The synthesis of these types of vectors is summarized, including the recent contributions to this field.

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Cationic Lipids Based on Phosphonate and Phosphoramidate Chemistry: Synthesis and Application to Gene Therapy

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