Calixarene Methylenebisphosphonic Acids: Alkaline Phosphatase Inhibition and Docking Studies

A. Vovk Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv, Ukraine

V. Kalchenko Institute of Organic Chemistry, NAS of Ukraine, Kyiv, Ukraine

O. Muzychka Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv, Ukraine

V. Tanchuk Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv, Ukraine

I. Muravyova Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv, Ukraine

A. Shivanyuk Institute of Organic Chemistry, NAS of Ukraine, Kyiv, Ukraine

S. Cherenok Institute of Organic Chemistry, NAS of Ukraine, Kyiv, Ukraine

V. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv, Ukraine

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Abstract

The inhibition of alkaline phosphatase from bovine intestine mucosa and bovine kidney by calix[4]arenes functionalized at the marcocyclic upper rim by one or two methylene bisphosphonic acid fragments have been investigated. The mechanisms of enzyme inhibition have been discussed using a molecular docking approach by computational modeling of inhibitors into active centers of E. coli alkaline phosphatase.

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Calixarene Methylenebisphosphonic Acids: Alkaline Phosphatase Inhibition and Docking Studies

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Calixarene Methylenebisphosphonic Acids: Alkaline Phosphatase Inhibition and Docking Studies

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