Synthesis and Mechanism Studies on Amide Bond Formation by Hexamethylphosphoramide (HMPA)

Jianbo Hou Department of Chemistry, The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P. R. China

Tongjian Wang Department of Chemistry, The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P. R. China

Kan Lin Department of Chemistry, The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P. R. China

Guo Tang Department of Chemistry, The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P. R. China

Yufen Zhao Department of Chemistry, The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P. R. China; The Key Laboratory of Bioorganic Phosphorus Chemistry, Department of Chemistry, School of Life Science and Engineering, Tsinghua University, Beijing, P. R. China

Abstract

In this paper, hexamethylphosphoramide (HMPA) was used as the organic phosphorus coupling reagent for the synthesis of amide bond. The reaction mechanism was tracked and investigated through ³¹P NMR.

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Acknowledgments

The project is supported by the National Natural Science Foundation of China (No. 20572061)

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Synthesis and Mechanism Studies on Amide Bond Formation by Hexamethylphosphoramide (HMPA)

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Synthesis and Mechanism Studies on Amide Bond Formation by Hexamethylphosphoramide (HMPA)

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