Silica-Supported Ferric Chloride (Silica-FeCl₃): A Reusable, Easily Controllable Catalyst for the Protection of Hydroxyl Groups under Mild and Ambient Conditions

Abstract

Diverse alcohols, phenols, and naphthols were converted into their corresponding trimethylsilyl ether effectively with hexamethyldisilazane in the presence of silica-FeCl₃ under solvent-free and ambient conditions with short reaction time in good to excellent yields. Work up procedure is easy, and the catalyst can be recovered by simple filtration and reused.

Keywords:

• Alcohols
• Hexamethyldisilazane
• Phenols
• Silica-FeCl₃
• Trimethylsilylation

Acknowledgments

We are thankful to the Sistan and Baluchestan University Research Council for the partial support of this work.

Notes

^aYields refer to the pure isolated products. All known products have been reported previously in the literature and were characterized by comparison of IR and ¹H NMR spectra with authentic samples. ^{20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34}