A Novel Approach Toward the Synthesis and Characterization of Pyrimidyl Chalcogen Compounds

Abstract

A variety of hitherto unknown symmetrical and unsymmetrical pyrimidyl chalcogen compounds have been synthesized and characterized by elemental analysis using various spectroscopic techniques viz. NMR ¹ H, ¹³ C, ⁷⁷ Se and infrared. Two different methodologies were employed. The first method involves the use of hydrazine hydrate as reducing agent to generate dichalcogenide anions followed by reaction with 2, 4-dichloropyrimidine to give the dichalcogenide compounds in good yield. The second method employs chlorine-magnesium exchange of 2,4-dichloropyrimidine using iso propyl magnesium chloride. The synthesis of the mixed phenyl pyrimidyl selenides have been achieved using sodium borohydride in ethanol as a reductive reagent to cleave Se-Se bond followed by alkylation with 2-chloro-4, 6-dimethylpyrimidine and 2, 4-dichloropyrimidine.

Keywords:

• 2,4-dichloropyrimidine
• diselenide
• pyrimidine
• selenium

Acknowledgments

The authors gratefully acknowledge the Department of Science and Technology, New Delhi, for financial support.