Preparation and Biological Activity of Some Novel Tetrachlorocyclodiphosph (V) Azane Pyridazine Derivatives and Its Metal Complexes

Abstract

1,3-diphenyl-2,2,4,4-tetrachloro-2,4-bis(4-Cyano-5,6-dimethyl-py-ridazin-3(2H)-one) cyclodiphosph(V)azane(III), reacts with stoichiometric amounts of transition metal salts such as Mn(II), Fe(III), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and UO₂(II) to afford colored complexes in a moderate to high yield. The complexes have been investigated in solution by the spectrophotometric molar ratio and conductometeric methods. The formula of the isolated complexes was suggested based on elemental analyses, IR, molar conductance, UV-Vis, ¹H NMR, mass spectra, solid reflectance, and magnetic susceptibility measurements. From the elemental analyses data, 1: 2 (III : M) ratio is suggested and the complexes are found to have the general formula [(MX_n)₂(III)(H₂O)_m].yX where M = Mn(II) (X = OCOCH ₃ , n = 2, m = 4, y = 0), Fe(III) (X = Cl, n = 2, m = 2, y = 2), Fe(II) (X = SO₄, n = 1, m = 2, y = 0), Co(II) (X = OCOCH₃, n = 2, m = 4, y = 0), Ni(II) (X = OCOCH₃, n = 2, m = 4, y = 0), Cu(II) (X = OCOCH₃, n = 2, m = 4, y = 0), Zn(II) (X = OCOCH₃, n = 2, m = 4, y = 0), Cd(II) (X = Cl, n = 2, m = 4, y = 0), and UO₂(II) (X = NO₃, n = 1, m = 0, y = 2). The IR and ¹H NMR spectral data revealed that III behaves as a neutral bidentate ligand coordinated to the metal ions through oxygen (O) and nitrogen N atoms. The UV-Vis, solid reflectance, and magnetic-moment data have shown that the ligands are coordinated to the metal ions in an octahedral manner. The molar conductance data show that the complexes are nonelectrolytes while the Fe(III) and UO₂(II) complexes are 1:2 electrolytes. The in vitro–biological activity of some newly synthesized compounds against gram-positive and gram-negative bacteria was studied.

Keywords:

• Cyclodiphosph(V)azane
• electronic
• infrared (IR)
• metal complexes
• magnetic moment