Synthesis and Antimicrobial Activity of Substituted Phenophosphazines

Abstract

Several Schiff base derivatives of phenophosphazines were synthesized by the reaction of amino phenophosphazines and aromatic aldehydes in equimolar ratio, using methanol as solvent. Possible structures have been proposed on the basis of elemental analysis, IR, and ¹H NMR spectral studies. The antibacterial and antifungal activities of the above mentioned Schiff base derivatives have been evaluated against pathogens E. coli, S. typhi, S. aureus, B. subtilis, A. niger, and C. Albicans.

Keywords:

• Antibacterial activity
• antifungal activity
• phenophosphazine
• Schiff base

Acknowledgments

The authors thank RSIC/CIL, Punjab University, Chandigarh for the spectral data and N. V. Patel College, Vallabh Vidyanagar, for antimicrobial studies.