Synthesis, Spectroscopic Studies, and In Vitro Antifungal Activity of Organosilicon(IV) and Organotin(IV) Complexes of 4-Amino-5-mercapto-3-methyl-S-triazole Schiff Bases

Abstract

The Schiff bases derived from condensation of s-triazole with heterocyclic aldehydes and their 1:1 and 1:2 complexes have been synthesized. These complexes have been characterized by elemental analyses, molar conductance and spectroscopic studies, including UV, IR, ¹H, ¹³C, ²⁹Si, and ¹¹⁹Sn NMR spectroscopy. On the basis of these studies, the resulting complexes have been proposed to have trigonal bipyramidal and octahedral geometries. The biological activity of these complexes against various fungi has been investigated.

Keywords:

• Antifungal activity
• metal complexes
• s-Triazole
• Schiff bases

Acknowledgments

This investigation received financial assistance from Kurukshetra University. Kurukshetra University provided University Research Scholarship (URS) to one of the authors (Dharampal). The authors are also thankful to the Head, RSIC of Panjab University, Chandigarh, for providing C, H, and N analyses.

Notes

*- Aspergillus terrus, A. alternata-Alternaria alternata, P. citrinum-Pencillium citrinum