Thieno[2,3-c]pyridazine Derivatives: Synthesis and Antimicrobial Activity

Abstract

Thieno[2,3-c]pyridazine 2 was selected as the starting material for the synthesis of some novel 5-arylidene amino and 5-thiazolidine derivatives. The structures of the synthesized compounds were elucidated by elemental analyses and spectral data. The antimicrobial and antifungal activities of the newly synthesized products were measured against some microorganisms.

Keywords:

• 5-Aminothieno [2,3-c] pyridazine
• 5-thiazolideno
• antimicrobial activity
• condensation with aldehydes, Mannish bases

Acknowledgments

The author acknowledges the help of Dr. Gamal El-Sherbeny, Department of Microbiology, Faculty of Science, El-Azhar University, Cairo, Egypt, for carrying out the antimicrobial activity.