Synthesis and Inhibitory Activity Against Epstein-Barr Virus of Some New 1,2,3,4-Tetrahydropyrimidine-2-thiones

Abstract

1,2,3,4-Tetrahydropyrimidine-2-thiones 4a–n were synthesized through the reaction of aromatic aldehydes 1a–n , ethyl acetoacetate (2) and thiourea ( 3) . The structures of all newly synthesized heterocyclic compounds elucidated by the use of IR, ¹H NMR, mass spectra, and elemental analyses. The inhibitory activity against the Epstein-Barr Virus early antigen (EBA-VA) of all newly synthesized heterocyclic compounds were evaluated.

Keywords:

• 1,2,3,4-tetrahydropyrimidinethione
• antigen
• ethylaceto-acetate
• Epstein-Barr Virus
• inhibitory activity
• and thiourea

The authors are grateful to Molecular Biochemistry Department, Kyoto Prefectural University of Medicine, Kawarmachi-dori, Kamigyo-Ku, Kyoto, Japan for biological evaluation.