Synthesis and Antimicrobial of Some Novel-5-carbomethoxy-2-pyridone Derivatives Containing Sulfonamide Moiety

Abstract

Dimethyl 4-(methoxymethylene)-2-pentenedioate 2 was selected as the starting material for the synthesis of some novel 2-pyridones containing sulfonamide moiety, which we expected to have biological activities such as bactericidal and fungicidal or other applications of certain interest.

Keywords:

• Antimicrobial activity
• coumalic acid
• p-substituted aniline
• n-substituted 5-carbomethoxy-2-pyridones

The author acknowledges the help of Dr. Gamal El-Sherbeney, Department of Microbiology, Faculty of Science, El-Azhar University, Cairo, Egypt, for carrying out the antimicrobial activity.