Synthesis and Antioxidant, Anti-Inflammatory, and Analgesic Activity of Novel Polycyclic Pyrimido[4,5-b]quinolines

Abstract

The behavior of the 2-methylthio-pyrimido[4,5-b]quinolin-4-one towards differently substituted amines is reported. Also, the reactivity of 3-aminothiazolo[3′,2′ :1,2]-pyrimido[4,5-b]quinoline-2-carbonitrile towards formic acid, urea, thiourea, formamide, and carbon disulfide is discussed. Some of the synthesized derivatives possess biological activities as anti-inflammatory and analgesic agents. Some of these selective biologically active compounds were screened for antioxidant properties.

Keywords:

• 3-Aminothiazolo-[3′,2′:1,2]pyrimido[4,5-b]quinoline-2-carbonitrile
• analgesic activities
• anti-inflammatory
• antioxidant
• 2-arylaminopyrimido[4,5-b]quinoline
• 2-methylthio

Notes

∗p < 0.5,

∗∗ p < 0.001 as compared with respective control.

^aP < 0.05: Statistically significant from control (Dunnett's test).

^bP < 0.05: Statistically significant from ASA (Dunnett's test).

∗ p < 0.5,

∗∗ p < 0.001 as compared with respective control.