Amine Exchange Reactions in Ionic Liquid

Abstract

An operationally simple, inexpensive, efficient, and environmentally friendly protocol for the amine exchange reactions of 3-N,N-dimethylaminopropiophenone and N,N-dimethylaminomethylferrocene with primary aryl amines is developed using the ionic liquid [bmim]PF ₆ as a solvent. The recovered ionic liquid can be reused for several cycles with constant activity.

Keywords:

• Amine exchange reactions
• 1-butyl-3-methyl imidazolium hexafluorophosphate
• Mannich bases

Notes

^a Reactions were carried out at room temperature.

^b All products were characterized by ¹H NMR and IR spectroscopy as well as by mass spectrometry.

^c Isolated yields.

^d Literature values in parenthesis.

^a Reactions were carried out at 60°C.

^b All products were characterized by ¹H NMR and IR spectroscopy as well as by mass spectrometry.

^c Isolated yields.

^d Literature values in parenthesis.