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Original Articles

Tetrachlorosilane-Zinc Chloride as a New Potent Binary Reagent for One-Pot, Three-Component Synthesis of Mannich-Type Products

, , , &
Pages 2799-2812 | Received 30 Jul 2008, Accepted 29 Oct 2008, Published online: 03 Nov 2009
 

Abstract

A combination of tetrachlorosilane and zinc chloride in dichloromethane as an efficient and ambient binary reagent to promote a one-pot amidoalkylation reaction of enolizable ketones, aromatic aldehydes with acetonitriles, or benzonitrile have been developed. The newly synthesized β-acetamidoketones 3 and β-benzamidoketones 5 were obtained in good yields.

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