Synthesis of Some New 2,4-Disubstituted Hydrazinothiazoles and 2,5-Disubstituted Thiazolidinones

Abstract

A series of hydrazinothiazoles has been synthesized by the condensation of thiosemicarbazones and α-bromoketones. Similarly the hydrazinothiazolidiones were prepared by the condensation of thiosemicarbazone and α-bromoesters. The newly synthesized compounds were characterized by NMR and LCMS studies.

Keywords:

• α-Haloketones
• hydrazine
• thiazole
• thiazolidinones
• thiosemicarbazone

We wish to thank Syngene International Limited for the generous support of spectral analysis. The author F. N. K. thanks DST, India, for their support of SERC–Fast Track Proposal funding.

Notes

^aAll products were identified by ¹H, ¹³C NMR, LCMS.

^bIsolated Yields.

^aProducts 6b, 6c, 7a, 7b were identified by ¹H, ¹³C NMR, LCMS.

^bIsolated Yields.