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Original Articles

Synthesis and Antimicrobial Activity of Some New Heterocyclic Schiff Bases Derived from 2-Amino-3-formylchromone

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Pages 2945-2958 | Received 11 Jul 2008, Accepted 13 Nov 2008, Published online: 03 Nov 2009
 

Abstract

Some new hydrazone derivatives 3a–e have been obtained from 2-amino-3-formylchromone (1). Heterocyclization of thiocarbohydrazone derivative 3e via reaction with some electrophilic reagents afforded 1,2,4-triazoles 6–8 and 1,2,4-triazines 913. Condensation reactions of aldehyde 1 with o-aminoaldehydes and/or ketones afforded some new isolated and condensed heterocyclic systems 17, 19, and 20. The newly synthesized compounds were screened for their antimicrobial activity.

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