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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 184, 2009 - Issue 12
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Original Articles

(N-Isocyanimino)triphenylphosphorane as an Efficient Reagent for the Synthesis of 1,3,4-Oxadiazoles from 3-Substituted Benzoic Acid Derivatives

Ali Ramazani Chemistry Department, Zanjan University, Zanjan, Iran
&
Ali Souldozi Chemistry Department, Islamic Azad University–Urmia Branch, Urmia, Iran
Pages 3191-3198 | Received 25 Oct 2008, Accepted 17 Dec 2008, Published online: 18 Nov 2009
 
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Abstract

The reaction of 3-substituted benzoic acid derivatives with (N-isocyanimino) triphenylphosphorane proceeds smoothly at room temperature to afford corresponding 1,3,4-oxadiazoles via an intramolecular aza-Wittig reaction in excellent yields under neutral conditions.

This work was supported by the Iran National Science Foundation (INSF) via the research project number 86053.20.

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