Synthesis of Dichloromethylphosphonates

Abstract

Efficient synthesis of O,O-dialkyl, O-alkyl-N,N-dialkylamido and N,N,N′,N′-tetraalkyldiamido dichloromethylphosphonates via treatment of O,O-dialkyl, O-alkyl-N,N-dialkylamido, and N,N,N′,N′-tetraalkyldiamido trichloromethylphosphonates with diethyl phosphite in the presence of triethylamine in ethanol has been described.

Keywords:

• Dichloromethylphosphonates

Dedicated to Professor Marian Mikołajczyk from the CBMiM PAN in Łódź, Poland, on the occasion of his 70th birthday.

Notes

^a Molar ratio (RO)₂P(O)CCl₃, HP(O)(OC₂H₅)₂, N(C₂H₅)₃ 1:1,2:1,2 was used.

^b Yields refer to isolated products.

^c Compound 2e cannot be obtained due to extensive dealkylation.