Recent Progress in Synthetic and Mechanistic Aspects of Phosphonate C-Radical Chemistry

Abstract

Progress in radical chemistry of C─C bond formation reactions as well as C-heteroatom (halogen, O, S, Se) and C─C bonds cleavage reactions under reductive conditions, involving phosphonate C-centered radicals, is reviewed with special emphasis on the achievements during the past seven years in iodine atom transfer addition (I-ATRA) and cyclization (I-ATRC) reactions, which were developed in this laboratory.

Keywords:

• I-ATRA and I-ATRC reactions
• phosphonate
• radical
• radical asymmetric induction
• radical C─C and C-heteroatom (halogen, S, Se) bonds scission
• radical C─C bond formation

Dedicated to Professor Marian Mikołajczyk, CBMiM PAN in Łódź, Poland, on the occasion of his 70th birthday.

Together with the representative of the young generation (A.B.), I (P.B.) would like to wish Professor Marian Mikołajczyk long years of further activity as a scientist and thank him for accompanying me in all stages of my scientific carrier. I also thank my collaborators A. Szadowiak (PhD), T. Białas (M.Sc.), and W. M. Pietrzykowski (M.Sc.) for their contribution to the radical chemistry of phosphonates.