A Facile and Clean Procedure for Preparation of α-Aminophosphonates via a Rotary Evaporator Equipped with Circulating Water Vacuum Pumps

Zhiyu Ju Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, Department of Chemistry, Zhengzhou University, Zhengzhou, China; College of Chemistry and Chemical Engineering, Xuchang University, Xuchang, China

Ruyi Zou Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, Department of Chemistry, Zhengzhou University, Zhengzhou, China

Yong Ye Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, Department of Chemistry, Zhengzhou University, Zhengzhou, China; Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China

Yufen Zhao Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, Department of Chemistry, Zhengzhou University, Zhengzhou, China; Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China

Abstract

RE-CWVP (rotary evaporator equipped with a circulating water vacuum pump)–assisted synthesis is reported as an extremely efficient, facile, and clean procedure for the preparation of α-aminophosphonates in organic synthesis and industrial processes. The title α-aminophosphonates are obtained in good to satisfactory yields by the method and characterized by means of IR, ¹H NMR, ³¹P NMR, ¹³C NMR, and mass spectrometry.

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Acknowledgments

The authors would like to thank the National Natural Science Foundation of China (Nos. 20602032, 20732004, and 20572061) for financial support.

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A Facile and Clean Procedure for Preparation of α-Aminophosphonates via a Rotary Evaporator Equipped with Circulating Water Vacuum Pumps

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A Facile and Clean Procedure for Preparation of α-Aminophosphonates via a Rotary Evaporator Equipped with Circulating Water Vacuum Pumps

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