Abstract
A series of fluorinated 2-(N-arylamino)-4-arylthiazoles (3) was synthesized by the condensation of appropriate arylthioureas (2) with corresponding α-bromoacetophenones (1) by using “green chemistry” techniques, viz. mechanochemical mixing and microwave or ultrasonic irradiation. Compared with conventional procedures, the reaction can be carried out under milder conditions, requiring a shorter reaction time and giving higher yields following the green chemistry methodology. All the synthesized compounds were characterized on the basis of elemental analyses and spectral data (IR, 1H NMR, and mass spectrometry). Representative compounds were also evaluated for their insecticidal activity against Helicoverpa armigera, and some of them showed promising activity.
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Acknowledgments
The authors wish to express their thanks to Dr. K. P. Madhusudanan, Deputy Director and Head, SAIF (Sophisticated Analytical Instrument Facility), Central Drug Research Institute (CDRI), Lucknow, India, for elemental analyses and spectral data. The authors are also thankful to Prof. P. S.Verma, Head, Department of Chemistry, University of Rajasthan, Jaipur, India, for providing necessary facilities and encouragement during the present investigation. One of the authors (D.S.) is grateful to the Centre of Advanced Studies (CAS), Department of Chemistry, University of Rajasthan, Jaipur, India, for award of JRF.