Synthesis of Novel Piperazine Phosphoramidate Analogues of 2-Arylquinolones

Zhibo Qu Key Laboratory of Organic Chemistry and Chemical Biology, Henan Province, Department of Chemistry, Zhengzhou University, Zhengzhou, P. R. China

Xiaolan Chen Key Laboratory of Organic Chemistry and Chemical Biology, Henan Province, Department of Chemistry, Zhengzhou University, Zhengzhou, P. R. China

Lingbo Qu Key Laboratory of Organic Chemistry and Chemical Biology, Henan Province, Department of Chemistry, Zhengzhou University, Zhengzhou, P. R. China; School of Chemistry & Chemical Engineering, Henan University of Technology, Henan Province, Zhengzhou, P. R. China

Jinwei Yuan School of Chemistry & Chemical Engineering, Henan University of Technology, Henan Province, Zhengzhou, P. R. China

Huina Li Key Laboratory of Organic Chemistry and Chemical Biology, Henan Province, Department of Chemistry, Zhengzhou University, Zhengzhou, P. R. China

Yufen Zhao Key Laboratory of Organic Chemistry and Chemical Biology, Henan Province, Department of Chemistry, Zhengzhou University, Zhengzhou, P. R. China; Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing, P. R. China

Abstract

A series of novel piperazine phosphoramidate derivatives of 2-arylquinolones were synthesized to improve their physicochemical and biological properties through a facile phosphorylating reaction. Their structures were elucidated by NMR, ESI MS, and HRMS.

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Acknowledgments

The authors would like to thank the Chinese National Science Foundation (No. 20472076) and Henan Academic Foundation of Science and Technology (No. 0512001400) for their financial support.

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Synthesis of Novel Piperazine Phosphoramidate Analogues of 2-Arylquinolones

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Synthesis of Novel Piperazine Phosphoramidate Analogues of 2-Arylquinolones

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