An Efficient, One-Pot Synthesis of Dialkyl 5-Hydroxy-4-aryl-2,5-dihydrofuran-2,3-dicarboxylate Derivatives

Abstract

The reaction between arylglyoxalmonohydrates, dialkyl acetylenedicarboxylates, and triphenylphosphine is described as a simple and efficient method for the synthesis of 5-hydroxy-4-aryl-2,5-dihydrofuran-2,3-dicarboxylate derivatives.

Keywords:

• Arylglyoxals
• dialkyl acetylenedicarboxylates
• 2,5-dihydrofuran derivatives
• intramolecular Wittig reaction
• triphenylphosphine