Novel Bioactive Thio- and Semicarbazide Ligands and Their Organosilicon (IV) Complexes

Abstract

Ligational behavior of thiosemicarbazones and semicarbazones derived from 1-phenyl-3-arylpyrazole-4-carboxaldehydes towards triphenylchlorosilane has been investigated by elemental analysis, molar conductivity measurements, and IR, ¹H, ¹³C, and ²⁹Si NMR spectroscopic studies. The ligands and their organosilicon complexes have also been evaluated for in vitro antimicrobial activity against some pathogenic bacteria and fungi.

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Keywords:

• Antimicrobial activity
• organosilicon (IV) complexes
• semicarbazones
• spectral studies
• thiosemicarbazones

Acknowledgments

The authors are grateful to the Sophisticated Analytical Instrumentation Facility (SAIF), Panjab University, Chandigarh, India, for providing NMR facility and elemental analysis.