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Original Articles

Synthesis of Diversified Thioethers, 1-Aroylalkylisoquinolin-1-yl Thioethers, by Electrophilic S-Alkylation of 3-Phenyl Isoquinoline-1(2H)-thione

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Pages 1932-1942 | Received 31 Jan 2009, Accepted 02 Oct 2009, Published online: 25 Aug 2010
 

Abstract

A mild and efficient method for the synthesis of thioethers has been developed. The 3-phenylisoquinoline-1(2H)-thione underwent S-alkylation to afford structurally diverse sulfides in high yield.

Acknowledgments

We thank the DST, India, for use of the CCD facility setup under the IRHPA-DST program at Indian Institute of Science, Bangalore, India. We also thank Syngene International Ltd., Bangalore, India, for their generous support in spectral analysis.

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