Facile, Three-Component Synthesis of Dithiocarbamate Derivatives With Potent Antimicrobial Activity

Abstract

A one-pot three component synthesis of alkyl/aryl-dithiocarbamic acid-3-oxo-3-(phenoxathiin-2-yl)-1-phenyl/(4-chlorophenyl)propyl esters (3a–n) was achieved from the reaction of 3-phenyl/(4-chlorophenyl)-1-(phenoxathiin-2-yl)propenones (1a,b), amine, and carbon disulfide. The antimicrobial activities of some compounds were also screened against some selected bacteria and fungi.

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Keywords:

• Antimicrobial activity
• dithiocarbamates; phenoxathiin

Acknowledgments

All strains were kindly supplied from Botany Department, Faculty of Science, Benha University, Benha, Egypt.