Synthesis and In Vitro Antimicrobial Activity of New α-Aminophosphonates via Tetrazolo [1,5-a] Quinoline Derivatives

Abstract

A series of diethyl (4-fluorophenylamino) (substituted tetrazolo[1,5-a]quinolin-4-yl)methyl phosphonate derivatives has been synthesized for the first time from tetrazolo [1,5-a] quinoline derivatives. Elemental analysis, IR, ¹H NMR, ¹³C NMR, and mass spectral data elucidated the structures of the all newly synthesized compounds. In vitro antimicrobial activities of synthesized compounds have been investigated against Gram-positive Bacillus subtilis, Gram-negative Escherichia coli, and two fungi Candida albicans and Aspergillus niger in comparison with standard drugs. Significantly, microbiological behavior of these newly synthesized derivatives possesses significant antibacterial and antifungal activity.

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Keywords:

• α-Aminophosphonate
• antibacterial
• antifungal
• tetrazolo [1,5-a] quinoline

Acknowledgments

The authors would like to thank the Head, Department of Chemistry, Dr. B. A. M. University, Aurangabad, for constant encouragement and providing necessary facilities. A.H.K. is thankful to University Grants Commission, New Delhi, India for a Research fellowship.