An Efficient Procedure for the Synthesis of Benzoxazole and Benzothiazole Derivatives Using a H₂O₂/SiO₂-FeCl₃ System

Abstract

A series of benzoxazole and benzothiazoles was readily prepared from the reaction of ortho-aminophenol/ortho-aminothiophenol and aldehydes using solid silica supported ferric chloride (SiO₂-FeCl₃) as catalyst followed by oxidation with H₂O₂ under ambient conditions. Some of advantages of this method are a simple and convenient procedure, easy purification, and shorter reaction times.

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Keywords:

• Aldehydes
• benzothiazoles
• benzoxazoles
• SiO₂-FeCl₃, H₂O₂

Acknowledgments

We are thankful to the Islamic Azad University of Yazd Research Council for the partial support of this research.

Notes

^a Isolated yields.

^a Isolated yields. All known products have been reported previously in the literature and were characterized by comparison of IR and NMR spectra with authentic samples. ³