A Simple and Effective Approach to the Via One-Pot Reactions in Water

Abstract

Water-accelerated synthesis of organic target molecules has been used as a key method for the preparation of phosphoryloxy phosphonate derivatives. Condensation reactions of acid chlorides with dialkyl (aryl) phosphites in the presence of N-methyl imidazole in water have been developed as efficient and clean green synthetic procedures for the preparation of phosphoryloxy phosphonates in high yields. This synthetic protocol provides rapid access to novel and diversely substituted phosphoryloxy phosphonate derivatives.

GRAPHICAL ABSTRACT

Keywords:

• Acid chloride
• dialkyl (aryl) phosphate
• N-methyl imidazole
• one-pot reactions
• phosphoryloxy phosphonates