Abstract
A model system is created that mimics natural ribosome as well as the way of ribozyme action. It uses oxirane analogue as condensation reagent and H3PO3 as activator for the carboxyl group and as protecting reagent for the NH2 function. In order to demonstrate the ability of the H3PO3/oxirane system to mimic natural peptide bond synthesis on the ribosome as well as to mimic the ribozyme synthesis and hydrolysis of an inter biomonomeric bond, four model compounds containing an amide bond were synthesized using phosphorous acid/oxirane mediators.
GRAPHICAL ABSTRACT
Acknowledgements
The financial support by the National Research Fund of Bulgaria for the purchase of a Bruker Avance II+ 600 NMR spectrometer in the framework of the Program “Promotion of the Research Potential through Unique Scientific Equipment” (Project UNA-17/2005) and the COST action CM0802 ‘‘PhoSciNet” is gratefully acknowledged.