Synthesis and Evaluation of 1-Aryl-1-(7-carboxy-isoindolin-1-one-2-yl)methylphosphonic Acid Derivatives as Inhibitors of Protein Tyrosine Phosphatase

Abstract

Isoindolin-1-one-2-ylmethylphosphonic acid derivatives have been synthesized as potential inhibitors of protein tyrosine phosphatases. Molecular docking calculations and assays in vitro showed that isoindolin-1-one-2-ylmethylphosphonic acid can be used as a scaffold for the design of new inhibitors of the enzymes.

Keywords:

• Inhibition
• isoindolin-1-ones
• molecular docking
• phosphonic acids
• protein tyrosine phosphatase