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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 186, 2011 - Issue 4: 18th International Conference on Phosphorus Chemistry (ICPC2010)
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IV. Biologically Relevant Organophosphorus Compounds

Phosphorylated Calix[4]arenes as Inhibitors of Glutathione S-Transferase

Andriy I. Vovk Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
,
Iryna M. Mischenko Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
,
Sergiy O. Cherenok Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
,
Vsevolod Yu. Tanchuk Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
,
Vitaly I. Kalchenko Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
&
Valery P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Pages 961-963 | Received 28 Jul 2010, Accepted 04 Aug 2010, Published online: 25 Apr 2011
 
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Abstract

Phosphorylated derivatives of calix[4]arene were evaluated as inhibitors of glutathione S-transferase. Computer-simulated docking studies showed that phosphorylated macrocycle is located near the G-site of the enzyme.

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