Synthesis of Calixarene-Methylenebisphosphonic Acids and Their Influence on Fibrin Polymerization

Abstract

A series of hydroxycalix[4]arenes bearing one, two, or four fragments of methylenebisphosphonic acids was synthesized by the reaction of appropriate formylcalixarenes with sodium salts of dialkylphosphites. These calixarenes inhibit specifically 50% of fibrin polymerization in the fibrinogen + thrombin reaction as well as monomeric fibrin desAABB polymerization in concentration up to 0.5 × 10⁻⁶ M.

Keywords:

• Calixarenes
• fibrinogen
• methylenebisphosphonic acids
• phosphonates
• thrombin