A Novel Approach to the Design of Phosphonate Inhibitors of Protein Tyrosine Phosphatase

Abstract

Inhibition of some PTPases by mono-, bis-, and tetrakisphosphorylated calix[4]arenes have been investigated. Kinetics and computational docking studies provide a basis for understanding the mechanism of enzyme–inhibitor complexation, which may be useful for the development of potent inhibitors of the PTPases.

Keywords:

• Calixarenes
• inhibition
• molecular docking
• phosphonates
• protein tyrosine phosphatases