Synthesis and Characterization of Novel Fluorescent Nitrogen-Containing Bisphosphonate Imaging Probes for Bone Active Drugs

Shuting Sun Department of Chemistry, University of Southern California, Los Angeles, California, USA

Katarzyna M. Błażewska Department of Chemistry, University of Southern California, Los Angeles, California, USA; Institute of Organic Chemistry, Technical University of Łódź, Łódź, Poland

Boris A. Kashemirov Department of Chemistry, University of Southern California, Los Angeles, California, USA

Anke J. Roelofs Bone & Musculoskeletal Research Programme, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK

Fraser P. Coxon Bone & Musculoskeletal Research Programme, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK

Michael J. Rogers Bone & Musculoskeletal Research Programme, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK

Frank H. Ebetino Warner Chilcott Pharmaceuticals, Cincinnati, Ohio, USA

Michael J. McKenna Harvard Medical School and Massachusetts Eye & Ear Infirmary, Boston, Massachusetts, USA

Charles E. McKenna Department of Chemistry, University of Southern California, Los Angeles, California, USA

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Abstract

Progress in the synthesis of novel fluorescent conjugates of N-heterocyclic bisphosphonate drugs and related analogues, together with some recent applications of these compounds as imaging probes, are briefly discussed.

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Acknowledgments

This work was supported by grants from the Alliance for Better Bone Health and the National Institutes of Health (1R01DC009837).

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Synthesis and Characterization of Novel Fluorescent Nitrogen-Containing Bisphosphonate Imaging Probes for Bone Active Drugs

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Synthesis and Characterization of Novel Fluorescent Nitrogen-Containing Bisphosphonate Imaging Probes for Bone Active Drugs

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