Approaches to Tyrosine-Linked Peptidomimetic Prodrugs of (S)-HPMP-Based Acyclic Nucleoside Phosphonates

Valeria M. Zakharova Department of Chemistry, University of Southern California, Los Angeles, California, USA

Ivan S. Krylov Department of Chemistry, University of Southern California, Los Angeles, California, USA

Michaela Serpi Department of Chemistry, University of Southern California, Los Angeles, California, USA

Boris A. Kashemirov Department of Chemistry, University of Southern California, Los Angeles, California, USA

Charles E. McKenna Department of Chemistry, University of Southern California, Los Angeles, California, USA

Abstract

Synthetic approaches to a new class of tyrosine-linked prodrugs of two 3-hydroxy-2-(phosphonomethoxypropyl) (HPMP) nucleotide analogues [(S)-HPMPC and (S)-HPMPA] are outlined.

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Acknowledgments

This work was supported by grants AI061457 and AI056864 from the National Institutes of Health.

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Approaches to Tyrosine-Linked Peptidomimetic Prodrugs of (S)-HPMP-Based Acyclic Nucleoside Phosphonates

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Approaches to Tyrosine-Linked Peptidomimetic Prodrugs of (S)-HPMP-Based Acyclic Nucleoside Phosphonates

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