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Abstract
Treatment of aromatic aldehydes with ammonia and hypophosphorus acid gave C 2-symmetric 1-aminoarylmethylphosphinic acids. The latter compounds, activated in the presence of hexamethyldisilazane (HMDS) or trimethylsilyl chloride (TMSCl), successfully reacted with methyl acrylate to afford symmetric pseudodipeptides. The applied synthetic approach is briefly outlined here.
Acknowledgments
The authors gratefully acknowledge support by the Institute for Advanced Studies in Basic Sciences (IASBS) Research Council under grant No. G2009IASBS120.
