Abstract
A mild and selective procedure for the synthesis of 4-carboxy thiazoles and thiazolidines starting from naturally occurring cysteine by condensation with aldehydes is described. The optimized procedure, taking advantage of the positive effect of microwave irradiation on the MnO2-mediated oxidation step, is suitable for multigram scale. Coordination of these ligands towards a variety of transition metal ions gave new interesting metallorganic supramolecular architectures in which an extensive 3D network is created through hydrogen bonding.
Acknowledgments
The authors thank Ente Cassa di Risparmio–Firenze through the motu proprio FIRENZE HYDROLAB project (www.iccom.cnr.it/hydrolab/) for supporting this research activity.