Ultrasound-Mediated Willgerodt–Kindler Reactions: Non-thermal Synthesis of Thioacetamides

Abstract

Non-thermal, solvent-free condensation of several aryl methyl ketones with amines and elemental sulfur is efficiently conducted using ultrasonic irradiation within short time periods. Consequently, various thioacetamides are conveniently synthesized. Similar experiments at controlled temperature (25 ± 1° C) resulted in comparable yields, showing the promotional role of ultrasound irradiation in the progress of the reaction.

GRAPHICAL ABSTRACT

Keywords:

• Multicomponent
• Willgerodt–Kindler reaction
• ultrasound irradiation
• solvent-free
• thioacetamide

Acknowledgements

Partial financial support by the Ministry of Science, Research, and Technology of Iran is greatly acknowledged.

Notes

^aIsolated yields.

^aIsolated yields.